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    Pharmaceutical Sciences Research Institute (PSRI)

    The Pharmaceutical Sciences Research Institute (PSRI) offers an alternative to traditional contract research organizations by providing research services in a highly cost effective and timely manner at the highest quality. 


    The PSRI offers a broad range of drug discovery and development services focused on the non-clinical setting. Our expertise is centered in dose formulation and bioanalysis across a wide variety of standard and unconventional biomatrices. 

    • Development and validation or transfer of analytical/bioanalytical methodologies in support of non-clinical dose range finding, PK, biodistribution (including CNS penetration), protein binding and various toxicology and safety assessment studies. 
    • Formulation optimization
    • Non-clinical analysis of small molecules and peptides in formulations and biological tissues and fluids. 

    We offer comprehensive in-vitro metabolism studies including: 

    • Metabolic stability
    • Metabolite identification
    • CYP450 phenotyping
    • Kinetics
    • Drug interactions

    These studies can be customized by the client to support selection of the optimal drug candidate. Studies are conducted in all commercially available non-clinical sub-cellular fractions (e.g., microsomes for phase I and S9 fractions for phase II). 

    Major Instrumentation/Software

    The PSRI utilizes the following instrumentation/software: 
    • AB Sciex API 3000 triple quadrupole and 4000 QTRAP mass spectrometers
    • Shimadzu Prominence LC20A binary high pressure liquid chromatography systems with DAD
    • LIGHTSIGHT 2.1 metabolism software
    • ANALYST 1.5.1 instrument control and data acquisition software
    • MULTIQUANT 2.0 multiple reaction monitoring software
    • Labsolutions Lite 5.5

    For more information or to request research, please contact Dr. Greg Gorman